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Colloquium
Speaker
Arvind Ramanathan (inStem, Bangalore)
Date & Time
Mon, 28 March 2022, 15:30 to 17:00
Venue
Online Colloquium
Resources
Abstract

There is an emerging understanding that aging is driven by a key set of conserved building blocks,, from C.elegnas to Vertebrates and humans. These building blocks involve nutrient signaling, DNA damage and the process of cellular senescence. Targeting these programs can compress morbidity and even increase maximum lifespan across species. I will tell you the story of how humans have come upon these insights and what this may hold for the future of our species. We will begin with early seminal experiments by Leonard Hayflick on replicative senescence, the discovery of key genetic regulators by Tom Johnson and Cynthia Kenyon, and lead into the present day insights into why we age and what role nutrients and senescent cells play in this.