Our cells, either short or long-lived, comprise non-membrane-bound compartments, e.g., ribosome and centrosome, and organelles, such as mitochondrion and cilium. Have you ever pondered: How are those nano-to-micro size compartments birth-homeostasis-death regulated? And what are the consequences of those compartments' deregulation?
Cases in point, a centrosome, the major cytoskeleton-organising and signalling centre of a eukaryotic cell, is made of amorphous peri-centriolar matrices that encapsulate two nano-cylinders (~3-10x106 nm3), called centrioles. These centrioles' numbers are tightly regulated in every cell of our body, and after cells exit the cell cycle, the same nano-cylinders template the cilia. The cilia are micro-protrusions, which are also called sensing hairs and cells' propellers. The alteration/deregulation of these structures at various ages of our lives causes several human diseases (collectively affecting 1:3 individuals).
Given the above-mentioned knowledge, I will discuss the newly uncovered mechanisms and unexplored biophysical questions on how centrosome-cilia birth and functions are regulated in time and space.
Zoom link: https://icts-res-in.zoom.us/j/93476518327?pwd=dm5hTFRKL3pzYi90dzg1N3IrTk1vQT09
Meeting ID: 934 7651 8327
Passcode: 202403