The biological functionality of cellular aggregates is a collective result of the activities and displacements of individual constituent cells. The theoretical characterization of this activity involves hydrodynamic transport coefficients, such as diffusivity and conductivity. Motivated by the clustering dynamics in bacterial microcolonies, we propose a model for active multicellular aggregates on 1D lattice. Employing macroscopic fluctuation theory, we derive a fluctuating hydrodynamics framework for this model system. Both semi-analytical theory and microscopic simulations reveal that non-equilibrium microscopic parameters exert a significant influence on the hydrodynamic transport coefficients, causing a notable decrease within the clusters. Additionally, we illustrate how the active nature of intercellular interactions disrupts the conventional Einstein relation that establishes a connection between transport coefficients and fluctuations. This study not only provides a comprehensive understanding of the hydrodynamic transport in bacterial microcolonies but also offers valuable tools for experimental investigations in other systems involving active cellular aggregates, such as tumor spheroids and organoids.
Zoom link: https://icts-res-in.zoom.us/j/92012666405?pwd=ZWRGRjAzSS9GN3NhMEprcVRPbGhJZz09
Meeting ID: 920 1266 6405
Passcode: 292930