| Time | Speaker | Title | Resources | |
|---|---|---|---|---|
| 14:00 to 15:30 | Maithreyi Narasimha (TIFR, India) |
Building cells
Morphogenesis refers to processes by which tissues and organs acquire the shape that is critical to their function. My lectures will aim to help you understand the general principles that govern how patterned structures are built in living systems. The shape of a tissue ‘emerges’ from the behavior of its constituent cells that include changes in number, shape and position. An organ is often built from many tissues. I will first discuss how cells are built and what governs the (often polarized) behaviors of single cells (in unicellular and multicellular organisms). I will highlight the importance of the polarized distribution of specific molecular complexes in generating polarized cell behavior and address how molecular complexes can be polarized. Building a tissue requires the spatial and temporal coordination of the behaviors of thousands of cells. I will discuss how chemical and physical cues enable cells to sense their neighborhood and modulate their behavior to ensure that the tissue is appropriately patterned. I will discuss the design principles of chemical and physical communication between cells and how they influence each other to control force production and to coordinate tissue deformation and large-scale movements. I will finally discuss how communication between tissues governs the formation of organs. I will discuss the development of ideas and methodologies that have helped our understanding of morphogenesis and how they have paved the way for reverse engineering tissues and organ‘oids’ in a dish.
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| 16:00 to 17:30 | Vijaykumar Krishnamurthy (ICTS, India) |
A condensed matter perspective of development TBA |
| Time | Speaker | Title | Resources | |
|---|---|---|---|---|
| 09:30 to 11:00 | Maithreyi Narasimha (TIFR, India) |
From cells to tissues: chemical communication Morphogenesis refers to processes by which tissues and organs acquire the shape that is critical to their function. My lectures will aim to help you understand the general principles that govern how patterned structures are built in living systems. The shape of a tissue ‘emerges’ from the behavior of its constituent cells that include changes in number, shape and position. An organ is often built from many tissues. I will first discuss how cells are built and what governs the (often polarized) behaviors of single cells (in unicellular and multicellular organisms). I will highlight the importance of the polarized distribution of specific molecular complexes in generating polarized cell behavior and address how molecular complexes can be polarized. Building a tissue requires the spatial and temporal coordination of the behaviors of thousands of cells. I will discuss how chemical and physical cues enable cells to sense their neighborhood and modulate their behavior to ensure that the tissue is appropriately patterned. I will discuss the design principles of chemical and physical communication between cells and how they influence each other to control force production and to coordinate tissue deformation and large-scale movements. I will finally discuss how communication between tissues governs the formation of organs. I will discuss the development of ideas and methodologies that have helped our understanding of morphogenesis and how they have paved the way for reverse engineering tissues and organ‘oids’ in a dish. |
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| 11:30 to 13:00 | Vijaykumar Krishnamurthy (ICTS, India) |
Random walks, diffusion and stochastic processes TBA |
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| 14:00 to 15:30 | Maithreyi Narasimha (TIFR, India) |
From cells to tissues: mechanical communication Morphogenesis refers to processes by which tissues and organs acquire the shape that is critical to their function. My lectures will aim to help you understand the general principles that govern how patterned structures are built in living systems. The shape of a tissue ‘emerges’ from the behavior of its constituent cells that include changes in number, shape and position. An organ is often built from many tissues. I will first discuss how cells are built and what governs the (often polarized) behaviors of single cells (in unicellular and multicellular organisms). I will highlight the importance of the polarized distribution of specific molecular complexes in generating polarized cell behavior and address how molecular complexes can be polarized. Building a tissue requires the spatial and temporal coordination of the behaviors of thousands of cells. I will discuss how chemical and physical cues enable cells to sense their neighborhood and modulate their behavior to ensure that the tissue is appropriately patterned. I will discuss the design principles of chemical and physical communication between cells and how they influence each other to control force production and to coordinate tissue deformation and large-scale movements. I will finally discuss how communication between tissues governs the formation of organs. I will discuss the development of ideas and methodologies that have helped our understanding of morphogenesis and how they have paved the way for reverse engineering tissues and organ‘oids’ in a dish. |
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| 16:00 to 17:30 | Vijaykumar Krishnamurthy (ICTS, India) |
Models of gene/protein dynamics, force-generation from polymerization -- |
| Time | Speaker | Title | Resources | |
|---|---|---|---|---|
| 09:30 to 11:00 | Maithreyi Narasimha (TIFR, India) |
Sculpting tissues, building organs Morphogenesis refers to processes by which tissues and organs acquire the shape that is critical to their function. My lectures will aim to help you understand the general principles that govern how patterned structures are built in living systems. The shape of a tissue ‘emerges’ from the behavior of its constituent cells that include changes in number, shape and position. An organ is often built from many tissues. I will first discuss how cells are built and what governs the (often polarized) behaviors of single cells (in unicellular and multicellular organisms). I will highlight the importance of the polarized distribution of specific molecular complexes in generating polarized cell behavior and address how molecular complexes can be polarized. Building a tissue requires the spatial and temporal coordination of the behaviors of thousands of cells. I will discuss how chemical and physical cues enable cells to sense their neighborhood and modulate their behavior to ensure that the tissue is appropriately patterned. I will discuss the design principles of chemical and physical communication between cells and how they influence each other to control force production and to coordinate tissue deformation and large-scale movements. I will finally discuss how communication between tissues governs the formation of organs. I will discuss the development of ideas and methodologies that have helped our understanding of morphogenesis and how they have paved the way for reverse engineering tissues and organ‘oids’ in a dish. |
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| 11:30 to 13:00 | Vijaykumar Krishnamurthy (ICTS, India) |
Hydrodynamics, mechanochemical patterns TBA |
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| 14:00 to 15:30 | Fernando Casares (CABD, Spain) |
The nature and action of genes (I) TBA |
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| 16:00 to 17:30 | Vidyanand Nanjundiah (Centre for Human Genetics, India) |
The interplay of development and evolution - I Developmental Biology used to be called embryology. It deals largely with multicellular development, which, as usually described, is the sequence of events beginning from the fertilised egg to the reproductively mature adult. Since unicellular forms preceded multicellular forms, it is obvious that the sequence must have evolved. Equally, it is obvious that the stages of development given above are incomplete. That is so because, as described, there is no way for the next generation to follow. Therefore the proper unit of development is not the cell, or organism (both of them being conventionally thought of as static entities), or the transition from embryo to adult (for the reason given), but the life cycle. Evolutionary developmental biology, "evo-devo" for short, deals with the development and evolution of life cycles. More than that, evo-devo has come to stand for a point of view that takes into account the manner in which future evolutionary potentialities are shaped by present developmental circumstances. The first of these two talks will present, in outline, a historical perspective on evo-devo and its ongoing transition to "eco-evo-devo"; the second will consider a specific case, namely the evolutionary origin of multicellular development. On the way we will come across the terms neo-Darwinism (or the Modern Synthesis), epigenetics, plasticity, and noise. |
| Time | Speaker | Title | Resources | |
|---|---|---|---|---|
| 09:30 to 11:00 | Maithreyi Narasimha and Vijaykumar Krishnamurthy (TIFR, India & ICTS, India) |
Self organised tissue architecture: morphogenesis in a dish Morphogenesis refers to processes by which tissues and organs acquire the shape that is critical to their function. My lectures will aim to help you understand the general principles that govern how patterned structures are built in living systems. The shape of a tissue ‘emerges’ from the behavior of its constituent cells that include changes in number, shape and position. An organ is often built from many tissues. I will first discuss how cells are built and what governs the (often polarized) behaviors of single cells (in unicellular and multicellular organisms). I will highlight the importance of the polarized distribution of specific molecular complexes in generating polarized cell behavior and address how molecular complexes can be polarized. Building a tissue requires the spatial and temporal coordination of the behaviors of thousands of cells. I will discuss how chemical and physical cues enable cells to sense their neighborhood and modulate their behavior to ensure that the tissue is appropriately patterned. I will discuss the design principles of chemical and physical communication between cells and how they influence each other to control force production and to coordinate tissue deformation and large-scale movements. I will finally discuss how communication between tissues governs the formation of organs. I will discuss the development of ideas and methodologies that have helped our understanding of morphogenesis and how they have paved the way for reverse engineering tissues and organ‘oids’ in a dish. |
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| 11:30 to 13:00 | Vidyanand Nanjundiah (Centre for Human Genetics, India) |
The interplay of development and evolution - II Developmental Biology used to be called embryology. It deals largely with multicellular development, which, as usually described, is the sequence of events beginning from the fertilised egg to the reproductively mature adult. Since unicellular forms preceded multicellular forms, it is obvious that the sequence must have evolved. Equally, it is obvious that the stages of development given above are incomplete. That is so because, as described, there is no way for the next generation to follow. Therefore the proper unit of development is not the cell, or organism (both of them being conventionally thought of as static entities), or the transition from embryo to adult (for the reason given), but the life cycle. Evolutionary developmental biology, "evo-devo" for short, deals with the development and evolution of life cycles. More than that, evo-devo has come to stand for a point of view that takes into account the manner in which future evolutionary potentialities are shaped by present developmental circumstances. The first of these two talks will present, in outline, a historical perspective on evo-devo and its ongoing transition to "eco-evo-devo"; the second will consider a specific case, namely the evolutionary origin of multicellular development. On the way we will come across the terms neo-Darwinism (or the Modern Synthesis), epigenetics, plasticity, and noise. |
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| 14:00 to 15:30 | Fernando Casares (CABD, Spain) |
The nature and action of genes (II): joint gene action and gene networks TBA |